If you have been looking into Rejuran Healer, you have probably wondered whether hand injection or the dedicated injector (Rejumate) is the better route. Plenty of what circulates online dismisses one method outright. This article sets out how the two delivery methods actually differ, and which situations each one suits.
What Rejuran Healer Is
Rejuran Healer is a skin booster that delivers polynucleotide (PN), sourced from salmon, into the dermis. PN is involved in restoring the skin's regenerative environment, and treatment is aimed at the overall condition of the skin: fine lines, texture, pores, firmness and tone. It is also notable for being licensed as an injectable administered directly into the skin. How strongly skin responds, and how long that lasts, differs from person to person.
Discomfort, the Long-Standing Hurdle
The best-known barrier to Rejuran Healer is discomfort during the procedure. The traditional method is hand injection, where the doctor places each point manually; because a relatively large volume enters with each pass, the pain burden tends to be higher. To ease that, PharmaResearch — the manufacturer — introduced a dedicated injection device called Rejumate. It uses a finer needle than hand injection and controls the volume delivered per pass, which lightens the discomfort. It is also designed to place the product at a consistent depth and spacing, and to reduce bruising and the raised bumps that can follow treatment.
The Misunderstanding About Product Loss
The claim that "injectors lose a lot of product while hand injection loses none" is widely repeated, but watching an actual procedure shows it is not that simple. With hand injection, too, it is not easy to place every point precisely in the dermis, and pressure from the syringe can push product back out to the surface. Judging an injector purely on the merits of hand injection, without having worked with the device, is not a fair comparison. Having used both approaches, SKINIQUE Clinic works with Rejumate as standard, while patients who prefer hand injection are treated that way.
Treatment Starts With the Director's Consultation and an Unopened Product Check
Before treatment, the attending director listens to your skin concerns directly and settles on a direction together with you. Through that consultation, the choice and the decision are left with the patient, so that no one is pushed toward a package they do not need.
Once treatment is decided, the product to be used is opened in front of you. The rule is that the full 2cc goes to one person, so there is no shortchanging the volume or diluting with another product. Wherever you go, we would suggest choosing a clinic that opens genuine product in front of you and lets you confirm it.
Comparing the Two Delivery Methods
There are five points in favour of delivering with Rejumate. First, controlling the volume per pass lightens the discomfort. Second, multiple micro-needles allow closely spaced delivery. Third, the product goes into the dermis at a consistent depth. Fourth, bruising and raised bumps are comparatively fewer. Fifth, the procedure takes less time.
Because of the micro-needles, it also handles sensitive, narrow areas such as around the eyes closely and evenly. Where a patient asks for the eye area in particular, the delivery zone can be adjusted to the areas requested.
Hand injection, by contrast, places a larger volume at wider intervals in a single pass, so more discomfort can be felt, and the depth of delivery varies with the operator's experience. Its strength is that a practised doctor can vary the intensity finely from area to area; conversely, where experience is limited, device delivery may be the steadier choice in terms of evenness.
In the End It Comes Down to Your Skin
Delivery method is less a question of which is superior than a choice shaped by your sensitivity to pain, the area being treated, and how much downtime you can allow. What matters most is hearing the differences explained fully and choosing to suit your own situation. Detailed costs can be found in the pricing guide.
Wrapping Up
Rejuran Healer is a skin booster that works on the skin's regenerative environment through PN, and hand injection and Rejumate each bring something different: fine manual control on one side, even device delivery on the other. If concern about pain has kept you putting treatment off, start by asking us in a chat about the delivery method that suits your skin.
This article was written by Dr. Park Tae-hyung, Chief Director. He is the chief director of SKINIQUE Clinic and serves as academic director of the Korean Society for Laser Dermatology and Trichology. First published December 16, 2021 · Last reviewed August 24, 2026
This article is general medical information. Skin condition and response to treatment vary from person to person. Whether to be treated, and how, should be decided through consultation.