Anyone looking into Rejuran runs into the same fork in the road: whether to have it injected by hand by a clinician, or delivered with Rejumate, the dedicated device. The accounts you hear about pain, injection marks and results tend to contradict one another, which only adds to the confusion, so this article compares the two methods calmly.
First, what kind of treatment is Rejuran
Rejuran Healer is a skin booster whose main ingredient is PN (polynucleotide). It is performed widely around the world and is sometimes nicknamed a "tonic for the skin."
PN is a biocompatible substance extracted and purified from salmon DNA. It supports the recovery of damaged skin cells and prompts collagen production, so it may help with firmness, hydration and fine lines. The key point is that it is not a treatment that fills something in to create volume for a while; it works on the skin's own regenerative environment.
Hand injection: strong on detail
With hand injection, the clinician controls needle depth and the amount delivered to each area directly by feel. That is why it has an advantage in areas where the skin is thin and sensitive, such as around the eyes and mouth, and in contoured areas that need fine adjustment. There are trade-offs, though. Discomfort during the session is comparatively greater, small raised bumps can be left at each injection point more noticeably, and the outcome depends heavily on the practitioner's experience.
The Rejumate method: even delivery and greater comfort
Rejumate is a dedicated injection device made by the company that developed Rejuran. Several fine needles enter at once and spread the product evenly across the face at a consistent depth. It tends to involve less discomfort than hand injection, fewer raised bumps and faster recovery, which suits anyone worried about pain or looking to treat the whole face evenly. That said, given how the device works, some product loss is possible.
The two methods at a glance
| Category | Hand injection | Rejumate |
|---|---|---|
| Discomfort | Comparatively strong | Comparatively mild |
| Raised bumps | Somewhat noticeable | Few |
| Product loss | Almost none | Some possible |
| Strength | Fine depth control, contoured areas | Even delivery, comfortable session |
| Suits | Focused work around the eyes and mouth | Whole-face care, sensitivity to pain |
In short, the guidance is this. If a specific area needs precise work, hand injection is the first thing to consider; if this is your first time with Rejuran and discomfort is a concern, or you want overall improvement across the face, Rejumate comes first. Of course, the judgement differs from person to person depending on the volume delivered, the area treated and the condition of the skin.
What matters more than the method
It is hard to declare that either one is simply better. What decides the actual outcome is less the delivery method itself than the experience and principles of the clinician who assesses the skin and plans the treatment.
SKINIQUE Clinic keeps to the following in Rejuran treatments. All products are genuine and used in the stated amounts, and each product is opened in front of the patient before the session, with the manufacturing date checked together. The delivery method and volume are adjusted to sensitivity to pain, and because the clinic is practised in both hand injection and Rejumate, it recommends whichever suits the condition of the skin rather than steering patients toward one of them.
Wrapping Up
Hand injection offers precision while Rejumate offers evenness and less discomfort, and the right answer depends on the condition of your skin and what you want from the treatment. Because results and recovery vary between individuals, the most important step is settling on a direction through a thorough consultation beforehand. If you are wondering which method suits you, start by asking through a chat consultation about Rejuran delivery methods.
This article was written by Chief Director Park Tae-hyung, Chief Director of SKINIQUE Clinic and an academic director of the Korean Society for Laser Dermatology and Trichology. First published September 11, 2025 · Last reviewed August 23, 2026
This article is general medical information, and skin condition and response to treatment vary between individuals. Whether to undergo treatment, and by which method, should be decided through an in-person consultation.