The skin around the eyes is the thinnest on the face, so signs of ageing such as fine lines and laxity tend to show there first. If under-eye and crow's-feet lines are a concern and eye cream is not making much difference, one option is to combine Rejuran I, which supports skin regeneration, with Xeomin eye Botox, which addresses expression lines. Below is a look at what each treatment does and the order in which they are actually carried out.
What is Rejuran I?
Rejuran I is a treatment in which polynucleotide (PN), a skin-regenerating ingredient, is injected intensively into the eye area. The aim is to help skin that has become thin and less resilient through irritation and ageing recover from within. Unlike eye creams and eye masks, which sit on the epidermis delivering moisture and nutrients, this approach targets the regeneration of the skin itself.
Where full-face Rejuran typically uses 2cc, Rejuran I concentrates 1cc into the eye area alone. Because it is focused on a small region, changes in fine lines, resilience and skin tone around the eyes, along with stimulation of collagen production, can be anticipated — though the degree of response differs from person to person.
Why Xeomin eye Botox is added
Rejuran I works on the condition of the skin itself, while lines that have already set in from repeated expressions call for a different role, which is where Botox comes in. Softening the crow's feet that fold when you smile with Xeomin creates a combination that addresses both the inside of the skin (Rejuran I) and its surface (Botox) at the same time. That is why Skinique Clinic runs the two treatments together as a single programme.
The order the treatment follows
When you visit, the doctor who will perform the treatment consults with you directly. Rather than recommending several treatments bundled into a package, the principle is to listen first to what you want to resolve and then guide you toward only the treatments that are genuinely needed. Once the plan is agreed, numbing cream is applied around the eyes and left for a set time, and just before the treatment begins the Xeomin and Rejuran products to be used are shown to you for confirmation.
The session itself starts with the eye Botox. Using an excessive dose in an attempt to erase every line can make expressions look unnatural, so the dose is adjusted to release only the lines that need releasing. The goal is not to reduce wrinkles to zero, but to restore a natural look.
Rejuran I, which follows, is known to involve some discomfort, so a drug-delivery device called Dermashine Pro is used. A tip fitted with nine micro-needles delivers around five to six passes per eye area, shortening the treatment time and easing the burden of discomfort.
Speed is not the only consideration. Gently stretching the skin so that the injections cover the entire under-eye and eye area without gaps is the kind of care that shapes the result. How much discomfort is felt varies between individuals, but numbing cream and device-based delivery help reduce it.
Aftercare immediately following the treatment
The eye area is sensitive right after the needles have passed intensively through it, so the session is finished with an ointment rather than any additional device-based care. Small marks and swelling can appear at the treated site, but these usually settle within a day or two, and recovery speed varies from person to person.
If you are wondering about the cost
Detailed costs for Rejuran I and Xeomin eye Botox are listed on the price guide.
Wrapping Up
Concerns around the eyes become much easier to approach when regeneration beneath the skin (Rejuran I) and expression lines on the surface (Xeomin eye Botox) are handled together. If you would like to know whether this combination suits the condition of your own eye area, you are welcome to ask through a chat consultation on the right approach for your eye area.
This article was written by Dr. Park Tae-hyung, Chief Director. He is the Chief Director of Skinique Clinic and serves as Senior Director of the Korean Academy of Laser, Dermatology and Trichology (KALDAT). First published November 19, 2023 · Last reviewed August 24, 2026
This article is general medical information. Skin condition and response to treatment vary between individuals. Whether and how to proceed with treatment should be decided through an in-person consultation.