Quite a few people are interested in skin boosters but keep putting them off because they are worried about the pain of the needle. Pluryal Refresh is one option such patients might consider: a skin booster formulated so that its active ingredients can reach the skin without being injected. This article outlines what it contains and the two treatment methods available at SKINIQUE Clinic.
What is in Pluryal Refresh
Pluryal Refresh is certified as a medical device in Europe and has been in use in more than 70 countries over the past 12 years. It has three core ingredients.
First, high-concentration hyaluronic acid (HA), at 50 mg per vial, supports the skin's hydration and firmness. Second, PN, a polynucleotide derived from salmon DNA, helps the skin barrier recover and supports firmness, while its anti-inflammatory action also contributes to calming the skin. Third, a plant stem cell booster prompts fibroblasts to differentiate, encouraging elastin production — in other words, supporting the skin's own regenerative process.
Vitamins A, B3, B5 and B6 are added on top, making it a multi-nutrient formulation that addresses wrinkles, the skin barrier and radiance at the same time, with a generous 5 cc per vial.
Method 1. Adding it to a laser treatment
If you are receiving triple or quattro toning and combining it with a laser that creates micro-channels in the skin, such as Potenza or Virtue RF, you can choose to add 1 cc of Refresh on top.
Because the active ingredients seep into the dermis through the micro-channels the laser has made, this combination allows a skin booster effect to be pursued in synergy with the laser, without direct injection.
Method 2. As a stand-alone treatment: MTS, BellaSonic, cryotherapy
The stand-alone treatment begins with a verification step: the product is opened in front of you and drawn up on the spot. Transferring the full 5 cc into the syringe and then showing you the empty vial is standard practice at SKINIQUE Clinic.
The first step is MTS. Fine channels are created across the surface of the skin, opening a path for the active ingredients to enter the dermis.
We make a point of covering areas that are easy to miss, including the nose.
Next, the BellaFact mode of BellaSonic adds ultrasound stimulation to take absorption a step further. Including this stage is standard at SKINIQUE Clinic for any skin booster treatment that does not use needle injection.
During the BellaSonic stage as well, detailed areas such as the nose, the eye area and around the mouth are worked over carefully.
The last step is cryotherapy. It helps the remaining product on the surface absorb while calming skin that has been stimulated by the treatment, and finishes with a soothing modelling pack. How the skin feels immediately afterwards, and the degree of improvement, vary from person to person.
Wrapping Up
What distinguishes Pluryal Refresh is that a composite skin booster based on HA, PN and plant stem cells can be received in a way that reduces the burden of pain. You can choose between combining it with a laser or having it as a stand-alone treatment, depending on the condition of your skin. Detailed costs are listed on our price guide. If you would like to know which method suits your skin, feel free to ask via chat for guidance on what suits your skin.
This article was written by Dr. Park Tae-hyung, Chief Director. He is the chief director of SKINIQUE Clinic and serves as academic director of the Korean Society for Laser Dermatology and Trichology. First published July 8, 2023 · Last reviewed August 24, 2026
This article is general medical information. Skin condition and response to treatment vary from person to person. Whether to undergo treatment, and by which method, should be decided through an in-person consultation.