Some people say their expression felt stiff after skin Botox, or that their skin gained no firmness after a glow injection. This happens because the two treatments have different characters. This article sets out how Skinique Clinic combines the strengths of both in the Zeobel treatment, and what the process looks like.
Skin Botox and glow injections, and the gaps each leaves
Botulinum toxin is normally used on muscle to soften wrinkles, and filler is used to restore volume where it has been lost. Inject small amounts of the two into the dermis rather than the muscle, however, and their role changes. Botulinum toxin placed in the dermis supports collagen production and takes part in improving fine lines and skin texture, while hyaluronic acid holds water in the dermis and helps the skin look hydrated and luminous. Yet toxin alone can leave dryness unaddressed, and hyaluronic acid alone can leave firmness unaddressed, so each is left with its own limit.
Why Xeomin and Belotero are blended
Zeobel, as the name suggests, is a treatment that blends Xeomin, a botulinum toxin product, with Belotero Soft, a Swiss hyaluronic acid filler. When both are placed into the dermis together, the hyaluronic acid fills in the dryness of a toxin-only treatment, and Xeomin, known for a low likelihood of resistance, covers the firmness that a glow injection alone leaves wanting. Because quality can differ between products even within the same category, the aim is to combine two proven products and reduce the possibility of resistance and inflammatory reactions. Responses to treatment vary from person to person.
The preparation, shown exactly as it happens
At Skinique Clinic, every product used in Zeobel is opened in front of the patient so that the use of genuine products in the stated amounts can be confirmed, and only then is the blend prepared. The process is as follows.
- 0.5 cc of Xeomin is drawn into a syringe, and 1 cc of Belotero Soft is opened.
- The two products are mixed evenly. Nothing beyond these two is added.
- A needle made for Dermashine Pro is fitted to the tip of the prepared syringe.
- A total of 1.5 cc of Zeobel is loaded into the Dermashine Pro device, and preparation is complete.
What Dermashine Pro delivery offers
Dermashine Pro, the device used for delivery, places the solution evenly into the dermis through nine fine needles. The needles are thinner than those of an ordinary syringe, so pain and lumping are less of a burden, and its improved negative-pressure technology is designed so that almost none of the solution is left behind in the cylinder and discarded, allowing precise and even delivery within a short time.
In the end, it comes down to who performs it
Even with the same product and the same device, the result can differ according to who carries out the treatment. Skinique Clinic works on the principle of an individually tailored approach: identifying the skin's problem points and the points to improve through a thorough consultation beforehand, then reflecting that in every stage of the treatment.
We see careful, area-by-area delivery by the medical staff, attentive down to the last drop, as the factor that divides satisfaction in this treatment.
Detailed costs can be found on the price guide.
Wrapping Up
Zeobel places Xeomin and Belotero Soft into the dermis together, aiming at the firmness of skin Botox and the hydration and glow of a glow injection in a single session, with even delivery by Dermashine Pro forming part of the same design. Since progress varies from person to person, if you are wondering whether it suits your skin, ask at Ask by chat about the right direction for your skin.
This article was written by Park Tae-hyung, Chief Director. He is the chief director of Skinique Clinic and serves as academic director of the Korean Society of Laser Dermatology and Hair. First published 7 April 2021 · Last reviewed 24 August 2026
This article is general medical information. Skin condition and response to treatment can vary from person to person. Please decide whether and how to be treated through a consultation.