If fine lines and hollowness around your eyes have started to bother you despite diligent use of eye cream, it may be time for care beyond the cosmetics stage. This article introduces SKINIQUE Clinic's eye wrinkle program, which pairs Rejuran I to support regeneration within the skin with Xeomin eye Botox to address surface wrinkles.
Why the Eye Area Ages First
The skin around the eyes is among the thinnest on the face, so it is where the signs of aging show first. Fine lines multiply, the under-eye area hollows, and dark circles deepen — changes that keep catching your eye in the mirror. One approach to consider at this point is the combination of Rejuran I and Xeomin eye Botox: Rejuran I supports regeneration inside the skin, while the eye Botox addresses the wrinkles that show on the surface, caring for the eye area inside and out.
Rejuran I: An Injection That Supports Dermal Regeneration Around the Eyes
Rejuran's main ingredient is polynucleotide (PN), a growth-factor complex extracted and purified from salmon, known to support regeneration of the dermal layer at a fundamental level. Rejuran I applies it intensively to the eye area. When the thin, elasticity-prone skin around the eyes is treated, improvements can be expected in fine lines, skin texture, skin density and elasticity, and dark circles — though the degree of response varies from person to person.
Rejuran is also a treatment many people hesitate over because of pain concerns. SKINIQUE Clinic uses the Dermashine Pro device to deliver the product quickly and evenly, reducing the pain burden while improving injection accuracy. We cannot say it is entirely painless, but it tends to pass quickly at a tolerable level.
Why We Use Xeomin for Eye Botox
There are many botulinum toxin products on the market, both Korean and international, but Xeomin is called a "pure toxin" for its low impurity content and is considered relatively less likely to induce resistance. As Botox treatments have become routine, managing resistance has grown more important, and SKINIQUE Clinic composes the Botox in its eye wrinkle program with Xeomin to ease that burden.
Just as important as the product is how it is injected. The eye area plays a large part in facial expression: too much and the expression turns unnatural, too little and satisfaction drops. Drawing on its accumulated Botox experience, SKINIQUE Clinic works to find the just-right dose — neither too much nor too little — treating wrinkles while keeping your expression natural.
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Wrapping Up
Eye-area aging involves both declining elasticity within the skin and surface wrinkles, so a dual approach — Rejuran I for the inside and Xeomin eye Botox for the outside — can be one option to consider. If you're curious which composition would suit your eye area, feel free to reach out via chat to discuss the right approach for your eye area.
This article was written by Dr. Park Tae-hyung, Chief Director of SKINIQUE Clinic and Senior Director of the Korean Society for Laser, Dermatology and Trichology. First published May 3, 2023 · Last reviewed August 24, 2026
This article is intended as general medical information; skin conditions and responses to treatment vary from person to person. Please decide whether and how to proceed with treatment through an in-person consultation.