The skin around the eyes is thin, which is why signs of aging tend to show there first. When fine lines and loss of elasticity arrive together, a single treatment alone often falls short — so this article walks through an approach that combines Rejuran I with eye-area Botox, from the underlying principles to how the procedure actually unfolds.
The Two Root Causes of Eye Wrinkles
Wrinkles settle around the eyes for two main reasons. One is the skin itself losing elasticity; the other is the repeated use of expression muscles when we smile or squint. Since the causes split in two, so does the improvement strategy: Rejuran I supports skin regeneration where elasticity has declined, while Botox modulates muscle movement where expression lines form.
Rejuran I and Xeomin: What Each One Does
Rejuran is an injectable that delivers salmon-derived PN (polynucleotides) into the dermis to encourage skin regeneration. Applied around the eyes, it can help refine the texture and elasticity of thinned skin from within.
Xeomin is a botulinum toxin formulated without complexing proteins. Used on expression-line areas, it can help soften wrinkles that have already set in and slow the deepening of lines in the same spot.
Fine lines and loss of elasticity in the thin skin around the eyes are rarely something a single treatment can handle on its own. Combining two different mechanisms — regeneration and muscle modulation — allows a more balanced change in both wrinkles and firmness, though the degree of improvement varies from person to person.
How the Procedure Unfolds
Before treatment, we show you the actual Xeomin and Rejuran products to be used and prepare the required amounts in front of you. Botox comes first. We examine where wrinkles form around and beneath the eyes and inject according to the depth of each line — the eye area is a spot where an imprecise approach can leave expressions looking unnatural, so delicate planning matters here more than anywhere.
In the Rejuran I step that follows, we use the Dermashine Pro device. Nine microneedles finer than a standard needle deliver the product while gentle suction holds the skin steady, allowing a denser, more even injection than manual technique, with less pain, bruising, and swelling.
Recovery immediately after treatment varies with skin condition, so please follow the aftercare guidance given on the day of your visit.
Wrapping Up
The answer to eye-area concerns starts with separating the causes. When declining elasticity is addressed through Rejuran I's regenerative mechanism and expression lines through Botox's muscle modulation, a natural-looking improvement can be expected. Detailed pricing is available in our price guide, and if you are wondering which combination suits your eyes, feel free to reach out via chat consultation about eye treatments.
This article was written by Dr. Park Tae-hyung, Chief Director of SKINIQUE Clinic and Senior Director of the Korean Society for Laser, Dermatology and Trichology. First published January 12, 2022 · Last reviewed August 24, 2026
This article is general medical information. Skin condition and response to treatment vary from person to person; please decide whether and how to proceed with treatment through an in-person consultation.