When you look in the mirror, the fine lines around your eyes and mouth are often the first thing you notice. For these delicate creases that makeup cannot hide, there is a treatment that takes a different route: replenishing collagen directly into the skin. Here is a step-by-step look at Laetigen, often called a "real collagen injection," and how it works.
Why lines appear around the eyes and mouth first
The skin around the eyes and mouth moves hundreds of times a day. Every expression folds and unfolds it, so fine lines settle here earliest and tend to deepen over time. On top of that, makeup often gathers in these micro-creases, making them look more pronounced than they are.
Where Botox and fillers are harder to apply
Wrinkles usually bring Botox or fillers to mind, but the fine crepey lines around the eyes, under-eyes, and mouth are an area those two treatments alone cannot fully address. Behind fine lines sits the collagen that gradually declines with age. Replenishing that depleted collagen, so the skin regains its own supporting strength, can be a more fundamental approach.
Laetigen, a skin booster that delivers collagen as it is
Laetigen is a collagen skin booster made of 99.9% pure type-I collagen. An improved purification process filters out impurities, and the formulation is stabilized at a neutral pH 7 — the same environment as the dermis — so it can be injected directly into the skin. Unlike ingestible collagen, most of which is broken down during digestion, Laetigen delivers collagen straight into the dermis of the area that needs it. That is the structural difference.
Three properties suited to delicate areas
Laetigen is frequently used around the eyes and mouth because of how the formulation behaves. First, the particles are fine, so there is less irritation even where the skin is thin. Second, the neutral formulation settles smoothly into the dermis, which tends to mean less swelling and fewer injection marks. Third, it spreads readily, so it works evenly across an area of fine lines. These properties generally mean less discomfort and shorter downtime than other skin boosters, which makes it a reasonable fit for sensitive areas.
What to expect, and how sessions are spaced
The changes people look for with Laetigen include softened fine lines, smoother skin texture, better hydration, and restored firmness. It is usually considered by those who are told they look tired because of crow's feet, or who are bothered by lines around the mouth and nasolabial folds. The degree of improvement varies from person to person. The manufacturer's baseline guidance is three sessions at roughly one-month intervals; at SKINIQUE Clinic we assess skin condition, age, and the depth of the lines to design an individual schedule. If you would like to know the cost, details are available on our price guide.
Combining it with lifting treatments
Planning Laetigen alongside lifting treatments that support collagen regeneration — Ultherapy, V-RO ADVANCE, Thermage, Sunny RF lifting, Sciton BBL SkinTyte, or Fortra Quattro — may offer added benefit for fine lines. Which combination suits you depends on your skin, so it is best discussed during consultation.
Wrapping Up
Laetigen is a skin booster that replenishes pure collagen directly into the dermis, addressing one of the underlying causes of fine lines around the eyes and mouth, with relatively little discomfort and a short recovery period. If you are wondering whether it is the right choice for your own lines, feel free to ask through our chat consultation on eye and mouth wrinkles.
This article was written by Dr. Park Tae-hyung, Chief Director. He is the Chief Director of SKINIQUE Clinic and serves as an academic director of the Korean Society for Laser Dermatology and Trichology. First published September 4, 2025 · Last reviewed August 23, 2026
This article is general medical information. Skin condition and response to treatment vary between individuals. Whether and how to be treated should be decided through an in-person consultation.