Once you start looking into skin boosters, the name you meet most often after Rejuran is exosomes. Both are described as treatments that support skin regeneration, but a clear explanation of how they differ, or of why exosomes are called a fourth-generation skin booster, is hard to find. This article walks through how ASCE+ exosome therapy works, how it differs from Rejuran, and how the treatment is performed at SKINIQUE Clinic.
Starting with the skin booster category
Skin boosters are a group of treatments that place ingredients involved in skin regeneration directly into the dermal layer, raising the skin's baseline condition. It is comparable to feeding nutrients into dry ground to revive the soil itself. Rejuran and exosomes both belong to this category, but the ingredients they carry are different. Rejuran delivers polynucleotide (PN) extracted from salmon into the dermal layer, filling out thinned skin and reinforcing firmness.
Exosomes, active ingredients derived from stem cells
An exosome is a tiny vesicle secreted by cells. ASCE+ is a product containing exosomes that ExoCoBio isolates from healthy stem cells using its patented technology. Research has reported that stem cell-derived exosomes help wound recovery and promote fibroblast proliferation and collagen synthesis.
For this reason ASCE+ exosome therapy is used with the expectation of support that goes beyond simple nourishment, in directions such as anti-inflammation, anti-aging, and skin barrier improvement. Unlike Rejuran, which uses ordinary cell-derived components, it uses a concentrated ingredient derived from stem cells, which is why it is classified as a fourth-generation skin booster. It is commonly considered for pores, acne scars, and troubled skin. Of course, the degree of response varies from person to person.
Half of it is how you get the ingredients absorbed
Exosomes are not an injectable; they are generally applied to the skin and then driven in, so a step that creates micro-channels in the skin is needed alongside. The basic approach is to create micro-punctures with MTS (microneedle therapy system) and let the ingredients absorb. At SKINIQUE Clinic we also run a method that combines the Potenza laser with a single-use Fusion Tip (pumping tip). Treating with Potenza, a microneedle radiofrequency device, raises the absorption efficiency of the active ingredients while at the same time aiming for skin improvement from the radiofrequency energy and a regenerative response from the microneedle stimulation.
How we verify that the product is genuine and fully used
ASCE+ is divided into a freeze-dried powder (part 1) and a solvent (part 2) to limit loss of potency, so it goes through a preparation step in which part 2 is added to part 1, mixed, and then drawn back out immediately before treatment. At SKINIQUE Clinic we show you the new product being opened and let you check its expiry date before treatment.
Once preparation is complete, we turn the empty vial upside down to show you that the entire solution has been used. The point is to let you confirm with your own eyes that one vial is not split among several people or diluted with other ingredients.
A single session's worth of ASCE+ prepared this way is 5cc, a larger volume than Rejuran (2cc) or NCTF (3cc).
The Potenza pumping tip procedure
The pumping tip used with Potenza is also single-use and never reused, and we open the new product in front of you.
There are two types of pumping tip depending on the number of needles, cp-16 and cp-25. The cp-25 is a denser configuration that can only be used with the upgraded new-model Potenza. SKINIQUE Clinic is equipped with this newer device and tip.
During treatment the exosome solution is placed on the skin surface a little at a time, and the negative pressure of the pumping tip draws the ingredients down into the dermal layer. Radiofrequency energy delivered from the needle tips reaches the same points at the same moment, so ingredient penetration and the skin's stimulation response work in tandem.
Areas where concerns tend to concentrate, such as the pores around the nose and the skin around the eyes and mouth, are worked over once more at a slower pace.
Detailed pricing is available on the price guide.
Wrapping Up
Exosomes are a fourth-generation skin booster that uses stem cell-derived components to support the skin's regenerative capacity, and they differ from Rejuran in the origin of the ingredient and the direction in which it acts. With any skin booster, how the ingredients are absorbed and how the product's authenticity and full dosage are managed matter as much as the ingredient itself, so we recommend choosing a clinic where you can verify these points. If you are wondering whether exosomes or Rejuran suit your skin better, ask us through chat for skin booster guidance tailored to your skin.
This article was written by Dr. Park Tae-hyung, Chief Director. He is the chief director of SKINIQUE Clinic and serves as an academic director of the Korean Society for Laser Dermatology and Hair. First published September 28, 2021 · Last reviewed August 24, 2026
This article provides general medical information. Skin condition and response to treatment vary from person to person. Whether and how to be treated should be decided through an in-person consultation.