If you have Botox regularly, at some point the thought tends to surface: "it doesn't seem to work as well as it used to." Around the question of resistance — something unavoidable in repeated treatment — this article looks at Coretox, a Korean botulinum toxin designed to lower the risk of antibody formation.
Repeat treatment and the problem of resistance
Botox is among the most widely accepted of all aesthetic treatments, since a simple injection can manage wrinkles and adjust the bulk of overdeveloped muscle. The effect is not permanent, however, so it has to be repeated at regular intervals — and if resistance develops during that process, the duration can shorten or the response itself can become blunted.
The basis of managing resistance risk is keeping to an appropriate dose and a sufficient interval between treatments. Beyond that, choosing a product from which the components capable of triggering antibodies have been removed in the first place is a more fundamental safeguard. Xeomin, made in Germany, has long been favoured for exactly that reason.
What makes Coretox different
Coretox is a Korean product released in 2019. It takes Xeomin's approach of removing unnecessary complexing proteins a step further by also excluding HSA (human serum albumin), with the aim of lowering the likelihood of antibody formation. Its characteristics are a lighter cost burden than imported products while pursuing the same direction on resistance management, and in our own clinical experience it is difficult to feel a clear difference from Xeomin. Response to any drug does, of course, vary between individuals.
How we work with Botox at SKINIQUE Clinic
SKINIQUE Clinic keeps both Xeomin and Coretox — the two products formulated to reduce resistance risk — in stock, so you can hear about the differences at consultation and then choose the one you prefer.
Treatment can be configured by area — wrinkles, masseter (jaw slimming), V-line and so on — and detailed fees are listed on our price guide.
The V-line Botox combination
V-line Botox bundles three treatments into one. Masseter Botox to reduce an overdeveloped masseter muscle, mouth-corner Botox to settle a downturned look around the mouth, and Dermatoxin (skin Botox) to firm the skin along the jawline are performed together, refining the lower face as a whole.
How the procedure runs
The sequence is straightforward: numbing cream is applied, you wait for it to take effect, and then the injections are given area by area.
Before injecting, we always go through a verification step in which we show you the product to confirm that it is genuine and to check its expiry date.
We then work through the mouth corners, masseter and jawline in order, adjusting injection points and dosage to the individual shape of your face. Because the degree of muscle development and the pattern of skin laxity differ from person to person, the actual design of the same V-line Botox varies from face to face.
Wrapping Up
To keep Botox working over the long term, it helps to have resistance management in mind from the moment you choose a product. Coretox is a Korean product with the potentially antibody-triggering components removed, and alongside Xeomin it is a strong option. Which product and which combination of areas suits your face is best decided in consultation, so start by asking us: chat with us about the right Botox for you.
This article was written by Dr. Park Tae-hyung, Chief Director. He is the Chief Director of SKINIQUE Clinic and serves as Senior Director of the Korean Society for Laser Dermatology and Trichology. First published October 12, 2023 · Last reviewed August 24, 2026
This article is general medical information. Skin condition and response to treatment vary from person to person. Whether to undergo treatment, and by what method, should be decided through an in-person consultation.