If no amount of moisturiser settles the tightness and dullness that seem to rise from within the skin, it may be time to look at the skin's own water reservoir rather than at what you apply on top. This article sets out how BYRYZN, a cross-linked hyaluronic acid skin booster, is administered, and how the combination treatment that adds Xeomin skin Botox is carried out.
Not every skin booster injection is the same
Hyaluronic acid (HA) sits at the centre of skin hydration. This component holds water within the dermis, and it declines naturally with age, which shows up as dryness, loss of firmness and fine lines. A skin booster injection replenishes that lost hyaluronic acid directly into the skin, but even under the same name, the character of the result can differ depending on which hyaluronic acid is used and at what concentration.
What sets BYRYZN apart from conventional skin booster injections
BYRYZN, made by Hugel, is a skin booster that has gone through a cross-linking process which joins hyaluronic acid molecules together like a chain. Greater cohesion from cross-linking slows the rate at which the material breaks down in the skin, which works in the direction of a longer-lasting hydrating effect, and the formulation is designed to contain at least 20 mg of hyaluronic acid per cc. It is also formulated with a balance of viscosity and elasticity intended to reduce the embossing sometimes mentioned with HA injections, where the skin surface takes on an uneven texture.
Skinique Clinic also offers a version in which Botox is mixed into BYRYZN before injection. This layers the fine-line, pore and texture benefits of skin Botox onto the hydration and glow that hyaluronic acid provides, all within a single treatment. Naturally, how strongly each of the two responds varies from person to person.
What gets decided in the consultation
Your visit begins with a consultation with the doctor. Replenishing moisture suits most skin types without much difficulty, but whether BYRYZN alone is enough for your current concern, whether adding skin Botox would serve you better, or whether a skin booster with a different composition would be more appropriate, all depends on the condition of your skin. You can decide whether to proceed once that judgement has been worked through together in the consultation.
Once the treatment is decided, the skin is cleansed and numbing cream is applied. Bringing the area around the eyes and mouth into the treatment range means the numbing stage has to cover them too, so we make it a rule to apply the cream broadly and thoroughly.
Checking the product — opened in front of you
Next, during preparation, the products to be used are shown to the patient first and opened on the spot. The expiry date is checked at the same time.
The same applies when you have chosen the Botox combination: the Xeomin or Korean-made botulinum toxin product is shown to you directly before it is opened. That the patient should be able to see with their own eyes which product is used and how much of it goes in is a sequence Skinique Clinic keeps to.
Once the checked BYRYZN and Botox are mixed, the injection is ready to begin.
The injection process with Dermashine Pro
The injection is carried out with the Dermashine Pro injector. Equipped with nine micro-needles along with negative pressure and automatic detection sensors, the device keeps the needle depth and the injected volume consistent, which helps secure speed and uniformity compared with hand injection while easing the burden of pain.
Managing the injection depth so that the material settles into the dermal layer rather than sitting on the surface is the key to this stage.
The whole face is covered evenly, while trickier areas such as around the eyes and mouth are approached as closely as is safe, and the areas you raised as concerns during the consultation are worked over once more at greater density. Immediately after the treatment, redness and needle marks may remain temporarily; a modelling mask then follows as a calming step before you go home. Recovery speed varies from person to person.
Detailed pricing is available on the price guide.
Wrapping Up
BYRYZN is a hyaluronic acid skin booster whose cross-linking process extends how long its hydrating effect holds, and combining it with Xeomin skin Botox is a way of approaching two directions, hydration and the care of fine lines and pores, in one treatment. If you are wondering whether the standalone or the combined treatment suits your skin, ask through a chat consultation about the skin booster that fits your skin.
This article was written by Dr. Park Tae-hyung, Chief Director. He is the chief director of Skinique Clinic and serves as academic director of the Korean Society for Laser Dermatology and Trichology. First published 9 February 2023 · Last reviewed 24 August 2026
This article is general medical information. Skin condition and treatment response may vary from person to person. Whether to undergo treatment, and which method to use, should be decided through an in-person consultation.